We are glad to announce that the DEEP-2 study Phase III multicentre, randomised, open label, non-inferiority active-controlled trial aimed at comparing for the first time the efficacy of deferiprone (DFP) versus deferasirox (DFX) in paediatric patients aged from 1 month to less than 18 years, affected by hereditary haemoglobinopathies has terminated and the results are available on EudraCT Database and at this link. Included in the DEEP (DEferiprone Evaluation in Paediatrics) project (FP7 GA n. 261483), DEEP-2 trial involved 393 patients recruited in 23 clinical centres in 7 EU and non-EU countries: Albania (2), Cyprus (1), Greece (1), Egypt (3), Italy (12), Tunisia (1), UK (3).
In particular, the study intended to investigate the changes in terms of ferritin levels and cardiac iron concentration in order to assess the non-inferiority of deferiprone compared to deferasirox in paediatric patients affected by hereditary haemoglobinopaties requiring chronic transfusions and chelation. Overall, the study provided evidence to support the use of DFP in paediatric patients.
Related posts:
DEEP-2: almost at the final rush
DEEP-2: an update of the clinical centres involved
Drug safety of oral iron chelator deferiprone in children: a dissertation on the results of DEEP-3 Study
The pilot study QuBo was presented at the 14th International Conference on Thalassaemia & Haemoglobinopathies and 16th TIF International Conference for Patients & Parents