deep-1 | DEEP Project https://www.deepproject.eu DEferiprone Evaluation in Paediatrics Sun, 10 Apr 2016 14:33:40 +0000 it-IT hourly 1 https://www.deepproject.eu/wp-content/uploads/2013/11/cropped-favicon3-32x32.jpg deep-1 | DEEP Project https://www.deepproject.eu 32 32 59896768 7th DEEP General Assembly meeting in Padua (Italy) https://www.deepproject.eu/7th-deep-general-assembly-meeting-in-padua-in-italy/ Fri, 25 Mar 2016 10:17:28 +0000 https://www.deepproject.eu/?p=2064 After the sad decision to cancel the General Assembly Meeting in Tunis, due to the disorders which have occurred across the country, the 7th DEEP General Assembly (GA) will take place in Padua (Italy) on April 13th -15th, 2016 with the participation of the whole DEEP Consortium as well as of external experts. Here you can […]

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After the sad decision to cancel the General Assembly Meeting in Tunis, due to the disorders which have occurred across the country, the 7th DEEP General Assembly (GA) will take place in Padua (Italy) on April 13th -15th, 2016 with the participation of the whole DEEP Consortium as well as of external experts.

Here you can find the final agenda of the Meetingwhich can be browsed even through mobile devices.

The meeting will be focused on a general update of the project’s activities, the progresses and achievements of the DEEP project as well as the finalization of the DEEP-2 and DEEP-3 studies, that are of utmost priority. Among others, the financial resources reallocation according to the recruitment performance at any involved centre will be discussed during the meeting.

In the same context of the GA meeting, the DEEP-2 Investigator Meeting and the 4th Open Meeting will take place.

In particular, the Scientific Open Meeting on April 15th, 2016 will entail two sessions:

   –  Challenges And Opportunities Of Conducting Clinical Trials In Paediatrics

   –  Management Of Thalassaemia And Haemoglobinopathies: An Ongoing Challenge

The Scientific Open Meeting will be the occasion to raise the attention on the progresses achieved by the clinical research and the challenges to be faced in conducting clinical trials in paediatrics, also highlighting the importance of the international cooperation through European Networks and the global initiatives to create synergies and foster clinical research. The second session will be more focused on the new pathways and therapeutic strategies for the management of thalassaemia and haemoglobinopathies and will also be the occasion to talk about the goals of the DEEP project.

More details on the event and the final agenda are available here and through our social network channels (Facebook and Google+).

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DEEP-1: results demonstrate that adults and children should use the same dose/Kg of deferiprone https://www.deepproject.eu/deep-1-efficacy-proven-also-in-small-children/ Wed, 08 Apr 2015 15:51:55 +0000 https://www.deepproject.eu/?p=1485 The DEEP-1 pharmacokinetic study evaluated the systemic exposure of DFP in the paediatric population aged from 1 month to < 6 years for which PK profile of deferiprone is unknown. This lack of information implies that so far the dosage of deferiprone in this age subset can only be calculated empirically based on adult data. Thus, the DEEP-1 study […]

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The DEEP-1 pharmacokinetic study evaluated the systemic exposure of DFP in the paediatric population aged from 1 month to < 6 years for which PK profile of deferiprone is unknown. This lack of information implies that so far the dosage of deferiprone in this age subset can only be calculated empirically based on adult data. Thus, the DEEP-1 study was aimed at providing the daily dosage most appropriate to ensure safety and efficacy in young children before enrolling them in DEEP-2.
Deferiprone exposures from 18 evaluable children aged from 1 month to < 6 yearsaffected by hereditary haemoglobinopathies confirmed that a dosing regimen of 25 mg/kg t.i.d.(i.e. 75 mg/kg/die) is the most mappropriate also in this specific age subset, with the possibility of titration up to 33.3 mg/kg t.i.d. (i.e. 100 mg/kg/die), if necessary.
For the first time, we have scientific evidence that the dosage of deferiprone used in adults can provide sufficient exposure to ensure efficacy also in small children.

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DEEP-1 Study Newsletter – Issue 2 https://www.deepproject.eu/deep-1-study-newsletter-issue-2/ Sun, 04 May 2014 09:56:03 +0000 https://www.deepproject.eu/?p=1304

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DEEP-1 Study Newsletter – Issue 1 https://www.deepproject.eu/deep-1-study-newsletter-issue-1/ Wed, 18 Dec 2013 09:46:54 +0000 https://www.deepproject.eu/?p=1294

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DEEP-1 – First patient enrolled! https://www.deepproject.eu/first-patient-enrolled/ Thu, 04 Apr 2013 10:07:08 +0000 https://www.deepproject.eu/?p=233 On January 31st, 2013 recruitment started in the DEEP-1 study (multi-centre, oral single dose experimental and modelling study to evaluate the pharmacokinetics of deferiprone in patients aged from 1 month to less than 6 years of age affected by transfusion-dependent haemoglobinopathies) and the first patient was enrolled at the Azienda Ospedaliera “A. Cardarelli” in Naples.

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On January 31st, 2013 recruitment started in the DEEP-1 study (multi-centre, oral single dose experimental and modelling study to evaluate the pharmacokinetics of deferiprone in patients aged from 1 month to less than 6 years of age affected by transfusion-dependent haemoglobinopathies) and the first patient was enrolled at the Azienda Ospedaliera “A. Cardarelli” in Naples.

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